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Since their approval in, the popularity of selective cyclooxygenase-2 COX2 inhibitors has swung from a domination of drug sales to serious disputes about their cardiovascular safety. Despite the numerous studies on COX2 inhibitors that have emerged, drawing conclusions about their cardiovascular safety has been complicated by conflicting results, underpowered clinical trials, and the lack of a placebo group and use of post hoc analyses in many trials. Nonetheless, certain conclusions can http://www.asscat.org be made with reasonable accuracy. It begins with a discussion of the several mechanisms proposed to explain how selective COX2 inhibition impacts the cardiovascular system. Finally, answers to key questions are provided to assist the clinician in devising a systematic approach to the risk-benefit analysis of COX2 inhibitors in actual practice. Author links open overlay panel Ignatius Gerardo E. CAD coronary artery disease. CHF congestive heart failure.
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To ascertain if etoricoxib increases the risk of gastrointestinal adverse events GAEs compared with placebo, diclofenac, and naproxen in the treatment of patients with osteoarthritis OA or rheumatoid arthritis RA. Randomized Clinical Trials RCTs that compared etoricoxib with placebo and other active drug for patients with OA or RA and reported data on gastrointestinal safety which is of interest to patients and clinicians were included.
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ARCOXIA is indicated in children and adolescents 16 erections of age and older for the symptomatic relief of osteoarthritis OA, rheumatoid arthritis RA, ankylosing spondylitis, and the brain and signs of inflammation associated with inborn gouty arthritis.
Nonsteroidal anti-inflammatory drugs NSAIDs have been widely used for the treatment of arthritic conditions.
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The NDA seeks indications for ARCOXIA for the treatment of osteoarthritis, rheumatoid arthritis, chronic low back pain, acute pain, dysmenorrhea, acute gouty arthritis and ankylosing spondylitis. VIOXX is Merck's once-daily medicine approved for the treatment of osteoarthritis, adult rheumatoid arthritis, management of acute pain in adults and primary dysmenorrhea.
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