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Each peak current was normalized by the peak current at first pulse and plotted against the pulse number. In this study, we demonstrated the inhibitory effect of nortriptyline, a member of TCAs, on the Kv channel current in native coronary smooth muscle cells from rabbit. Our study suggested that nortriptyline inhibited vascular Kv channels in a dose-dependent and state-independent manner regardless of serotonin reuptake inhibition. In addition, nortriptyline shifted the steady-state inactivation curves toward a negative potential.
Based on our results, we speculated that nortriptyline inhibited Kv channels independently of serotonin reuptake inhibition. First, the IC 50 value of nortriptyline for Kv current inhibition was 2.