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All other participants will be scheduled for a randomization visit in one week at which time the auto-antibody results will be available; positive auto-antibodies are required for randomization. Safety assessments will be made throughout the study by querying about episodes of severe hypoglycemia and diabetic ketoacidosis DKA. Drug will be double blinded. Drug dose will be weight-dependent and will be escalated at week intervals, up to a weight-dependent maximum if tolerated. Cohort A will have additional safety visits 1 week after initiation of study drug and after each study drug dose increase, to test blood pressure and pulse. Over the course of the trial, study drug dose may be decreased or discontinued if side effects occur. Placebo will be taken orally once per day by participants in Cohort A.
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Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, 16 and was the first calcium channel antagonist to be introduced into therapy in the early s. A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Verapamil is indicated in the treatment of vasopastic i. Prinzmetal's angina, unstable angina, and chronic stable angina. It is also indicated to treat hypertension, for the prophylaxis of repetitive paroxysmal supraventricular tachycardia, and in combination with digoxin to control ventricular rate in patients with atrial fibrillation or atrial flutter.
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Verapamil is a calcium channel blocker whose main indication in veterinary medicine is in the treatment of supraventricular arrhythmias in dogs.
Verapamil, a calcium channel blocker, is classified as a class IV anti-arrhythmic agent. It is used in the treatment of hypertension, as an important therapeutic agent for angina pectoris, ischemic heart disease, hypertension and hypertrophic cardiomyopathy.
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