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These cytokines and cells then fight the virus infection, but their presence also partly obstructs the air sacs where oxygen exchange occurs. Researchers are now considering add-on therapies that partly limit the inflammatory response by blocking the effects of certain cytokines and chemokines. These add-on therapies include antibody-based drugs, such as tocilizumab that blocks the interleukin-6 cytokine receptor or leronlimab that blocks the chemokine receptor CCR5.
When cytokine receptors and chemokine receptors are blocked then it matters less that there are high levels of cytokines or chemokines, because their effects are significantly minimised. Although this would require caution for careful dosing, and these drugs would need to be co-administered together with an antiviral drug.
Chloroquine, a well-known anti-malarial drug, has also gained attention.