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Common side effects include confusion and sleepiness. Some documented side effects include. Because of potential for more severe side effects, this drug is on the list to avoid in the elderly. Promethazine is listed as one of the drugs of highest anticholinergic activity in a study of anticholinergenic burden, including long-term cognitive impairment. Promethazine, a phenothiazine derivative, is structurally different from the neuroleptic phenothiazines, with similar but different effects. Another notable use of promethazine is as a local anesthetic, by blockade of sodium channels. Slow oxidation may occur upon prolonged exposure to air, usually causing blue discoloration.

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Oestrogen occurs naturally in the female body and is responsible for regulating many processes, which is why menopause can cause many uncomfortable symptoms, including hot flushes, night sweats, vaginal dryness, loss of sex drive, incontinence and loss of bone mass. Premarin is used to alleviate the symptoms of menopause where they are particularly uncomfortable, in particularly. Lower oestrogen levels put women at a higher risk for certain illnesses like osteoporosis, a bone disease which can lead to fractures.

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