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Oxybutynin appears to be an effective oral antimuscarinic drug for overactive bladder; 3 however, its use is limited by common and sometimes intolerable side effects including dry mouth, constipation, blurred vision, impaired voiding and confusion, especially in the elderly. The most common reason for discontinuing treatment was adverse effects. A transdermal delivery system was developed in an attempt to decrease the active metabolite levels, and side effects, by avoiding presystemic metabolism in hepatic and intestinal enzyme systems. The oxybutynin patch is manufactured by Watson Pharmaceuticals, Inc. Food and Drug Administration in April
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