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Lever pressing by squirrel monkeys was maintained under second-order schedules of either food presentation or IM cocaine injection. The two types of second-order schedules generated distinctly different patterns of responding. Furthermore, the temporal distribution of responding maintained by food presentation or cocaine injection sometimes differed slightly under the same schedule. Food presentation or cocaine injection occurred only at the end of each daily session, thereby allowing assessment of the effects of presession administration of cocaine, chlorpromazine CPZ, and chlordiazepoxide CDP on responding at times when the direct effects of consequent cocaine injections were minimal or absent. Presession treatment with suitable doses of cocaine increased low rates of food- or cocaine-maintained responding under both types of second-order schedules, whereas CPZ only decreased responding. CDP increased responding in some monkeys, whereas in other monkeys it had little or no effect.


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Alex Liber, M. Nighttime high blood pressure could harm the brain, a new study says. Folks with high blood pressure and reverse dipping may be at increased risk for vascular damage in the brain and associated

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