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In pregnancy, maternal serum concentrations of calcitriol significantly rise as a result of increased renal and placental contribution in order to assure calcium supply for the developing fetus. In the present work we studied calcitriol actions upon human chorionic gonadotropin hCG secretion and expression in cultured trophoblasts, as well as vitamin D receptor VDR and CYP27B1 immunolocalization in placental villi. Expression studies were carried out by real time PCR. CYP27B1 was immunolocalized in the syncytiotrophoblast layer of placental villi. Vitamin D is metabolized to the steroid hormone 1,dihydroxyvitamin D 3 or calcitriol, which regulates calcium homeostasis, modulates the immune response, and promotes cellular differentiation, among other actions.
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