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Do not use tablets as first-line treatment; should be used only when other effective antifungal therapy is not available or tolerated and the potential benefits are considered to outweigh the potential of hepatotoxicity. Avoid prescribing tablets to treat skin and nail fungal infections owing to risk of serious liver damage, adrenal gland problems, and harmful interactions with other medicines that outweigh its benefit in treating these conditions, which are not approved uses of the drug these indications were removed from labeling by the FDA in Tablets should be used only when other effective antifungal therapy is not available or tolerated and the potential benefits are considered to outweigh the potential risks. Hepatotoxicity has occurred with oral use, including some fatalities or requiring liver transplantation; reported with oral administration of drug; some patients had no obvious risk factors for liver disease. May cause QT prolongation; coadministration with dofetilide, quinidine, pimozide, cisapride, disopyramide, dronedarone, and ranolazine is contraindicated; ketoconazole can cause elevated plasma concentrations of these drugs by CYP3A4 inhibition and may prolong QT intervals, sometimes resulting in life-threatening ventricular dysrhythmias such as torsades de pointes.
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It is not clear whether this was due nizoral tablet cost the combination of therapy. These may be an indication of hepatitis hepatitis. Hepatotoxicity has been reported https://www.fivecolleges.edu with restarting oral ketoconazole rechallenge. Some patients had no obvious risk factors for liver disease. Do not take two doses on the same day. Do not take double doses to compensate for forgotten doses?
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