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Beta-blockers are prescribed to millions of people for treatment of hypertension. Fatigue is a recognized and common side effect of beta-blockers that can have significant effects on quality of life. Worse, many people taking a beta-blocker for years are not even aware of the reduction of energy with which they are living. A new vasodilating beta-blocker, nebivolol, which is approved by the FDA for treatment of hypertension, appears to be far less associated with fatigue than are most currently available beta-blockers. The purpose of this study is to compare nebivolol with the current best-selling beta-blocker, metoprolol, and determine whether there is a significant difference in side effects including fatigue, reduced exertion tolerance, and reduced quality of life.
Metoprolol is prescribed to treat angina pectoris, heart failure, mild to moderate high blood pressure and to improve survival after heart attack. Classes: Beta-adrenergic blocker, antianginal, antiarrhythmic, antihypertensive, antimigraine. Angina pectoris, heart failure, mild to moderate high blood pressure, and to improve survival after heart attacks. Also effective in treating arrhythmias, pheochrocytoma, essential tremor and neuroleptic drug-induced movement disorders, preventing migraine headaches, reducing eye pressures in glaucoma, and reducing the frequency of vasovagal syncopal episodes. May have a role in treatment of aggressive behavior, panic attacks, and reducing atherosclerosis. There is considerable evidence that preoperative treatment with metoprolol or other beta-blocker is associated with a significant reduction in adverse cardiac events during and after surgical procedures.
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