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Some commonly reported antidepressants have almost no difference whatsoever on OCD symptoms.
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This open-label, pilot episode was designed to investigate the duration, safety and tolerability of escitalopram in preparations up to 50 mg in MDD.
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Early publications suggested that dual-acting agents such as venlafaxine and duloxetine, which inhibit both serotonin and norepinephrine reuptake, may offer greater efficacy in treating depressed patients to remission compared with SSRIs. In this study, escitalopram treatment resulted in significantly greater improvement compared with duloxetine on the prospectively defined primary efficacy endpoint of change from baseline in MADRS total score LOCF ; analysis of patients completing 8 weeks of treatment did not achieve statistical significance. This greater improvement in MADRS total score using the LOCF approach for the escitalopram group https://www.mdproactive.com compared with the duloxetine group may be attributed to a high discontinuation rate in duloxetine-treated patients. Post hoc analysis found that escitalopram and duloxetine also produced comparable symptom improvement on individual HAMD tic items i. On the whole, these findings do not substantiate previous assertions that a dual-acting agent is necessary to achieve high rates of therapeutic response and remission.
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