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For the treatment of early localized or early disseminated Lyme disease manifested as erythema migrans, in the absence of specific neurologic involvement or advanced atrioventricular AV heart block, the IDSA, AAP, and other clinicians recommend that adults receive oral doxycycline in a dosage of mg twice daily for 14 days range days.
If necessary e. If concerns exist regarding tolerance or drug interactions in an individual patient, it may be advisable to initiate doxycycline prophylaxis weeks prior to departure to ensure that the drug or combination of drugs in individuals receiving other drugs is well tolerated and to allow ample time to switch to another antimalarial agent if required.
Because doxycycline cannot prevent delayed primary attacks or relapse of P. If doxycycline is used in conjunction with quinine sulfate for presumptive self-treatment of malaria in the event of an influenza-like illness e.