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A predominantly sensory peripheral polyneuropathy has been observed in patients receiving long-term phenytoin therapy. Acute hepatic failure, toxic hepatitis and liver damage See Section 4. Coarsening of the facial features, enlargement of the lips, gingival hyperplasia, hirsutism, hypertrichosis, Peyronie's Disease and Dupuytren's contracture may occur rarely.
Haemopoietic complications, some fatal, have occasionally been reported in association with administration of phenytoin. These have included thrombocytopenia, leucopenia, granulocytopenia, agranulocytosis, pancytopenia with or without bone marrow suppression. Macrocytosis and megaloblastic anaemia have occurred, Lymphadenopathy including benign lymph node hyperplasia, pseudolymphoma, lymphoma, and Hodgkin's disease have been reported see Section 4.