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India has nearly 70 million people suffering from Diabetes. As most of Indian Diabetic patients are not covered by health insurances or Government Health schemes, they have to shell out large sums of money from their pockets for health care. Ever since its launch in, Pioglitazone has proved to be a very effective medicine for reducing blood sugar. Pioglitazone can induce certain side-effects like weight gain, edema, increased chances of fractures and slight increase in bladder cancer in certain patients. Absence of Pioglitazone as a treatment option in Diabetes will severely restrict a patient's ability to put his or her Diabetes under control.

Since their introduction to clinical practice in the s, sulfonylureas have been widely prescribed for use in patients with type 2 diabetes. Moreover, current arguments also suggest that the alternative drugs may be superior to sulfonylureas with regard to the risk of cardiovascular complications. Therefore, given the current controversy, we provide a Point-Counterpoint on this issue. In the preceding point narrative, Dr. In the counterpoint narrative below, Dr. They state that no priority is intended by the order in which the five classes are listed. Do other agents have an equal or lesser burden of adverse effects, particularly hypoglycemia, than SUs. These comparisons included pioglitazone versus gliclazide and rosiglitazone versus glyburide or gliclazide or glimepiride. However, the results with insulin can be superior, given no limitation on its doses.

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The introduction of generic Actos should substantially reduce the price of the drug. This means Actos now has significant potential as a low-cost treatment for type 2 diabetes, which could mean healthcare providers will become more likely to recommend its use. These drugs potently lower blood glucose levels by making the body more sensitive to insulin. First approved in, Actos is currently the only drug in this medication class to be widely available in the US and Europe. Actos also has a number of side effects including weight gain and bone fractures, and clinical studies have more recently revealed an increased risk of bladder cancer in people taking Actos see new now next in diaTribe

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Insulin could be utilized at any place when required and in this regard outcomes reduction with an initial glargine intervention ORIGIN study also suggested that basal insulin glargine could be safely used even in early stage. The glucose lowering did depend in part on the study design populations and baseline glycated hemoglobin HbA1c levels.

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