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The effect that such symptomatic suppression has upon the long-term course of tardive dyskinesia is unknown. Risperidone should be prescribed in a manner that is most likely to minimize the occurrence of tardive dyskinesia. Chronic antipsychotic treatment generally should be reserved for patients who suffer from a chronic illness that is known to respond to antipsychotic agents, and for whom alternative, equally effective, but potentially less harmful treatments are not available or appropriate. If signs and symptoms of tardive dyskinesia appear in a risperidone-treated patient, risperidone discontinuance should be considered; however, some patients may require continued treatment with the drug despite the presence of the syndrome. At recommended therapeutic dosages of risperidone mg daily for schizophrenia, the severity of extrapyramidal reactions appears to be comparable to placebo and clozapine mg daily, and substantially less than that associated with haloperidol 10 or 20 mg daily. Neuroleptic malignant syndrome NMS, a potentially fatal syndrome requiring immediate discontinuance of therapy and intensive symptomatic treatment, has been reported in patients receiving antipsychotic agents, including risperidone.

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