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Common side effects include dry mouth, constipation, loss of appetite, sleepiness, weight gain, sexual dysfunction, and trouble urinating. Clomipramine was discovered in by the Swiss drug manufacturer Ciba-Geigy. In a meta-analysis of various trials involving fluoxetine Prozac, fluvoxamine Luvox, and sertraline Zoloft to test their relative efficacies in treating OCD, clomipramine was found to be the most effective. Contraindications include. Clomipramine use during pregnancy is associated with congenital heart defects in the newborn.
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