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In this study, we aimed at determining electrocardiogram changes of donepezil administration in elderly patients with ischemic heart disease, who tend to suffer from cognitive disorders. These data demonstrated that donepezil administration decreased HR, prolonged PR interval, and increased parasympathetic function without affecting QRS duration and QT intervals, suggesting that it can be used safely in elderly patients with ischemic heart disease. Some of them suffer from cognitive impairment. Therefore, combination therapy with cardiovascular https://www.riteaid.com and psychiatric drugs is very common. By inhibiting the enzyme acetylcholinesterase, cholinesterase inhibitors reduce breakdown of acetylcholine, which is associated with the improvement in memory function.
Patients must have been taking 10 mg IR or a bioequivalent generic for at least 3 months prior to Screening. The study will consist of 24 weeks of daily administration of study medication, with clinic visits at Screening, Baseline, 3 weeks safety only, 6 weeks, 12 weeks, 18 weeks and 24 weeks or early termination. Patients will receive either 10 mg donepezil IR in combination with the placebo corresponding to 23 mg donepezil SR, or 23 mg donepezil SR in combination with the placebo corresponding to 10 mg donepezil IR. A total of approximately patients will be enrolled to obtain complete data from approximately completed patients Revised per Amendment During the Baseline visit, patients will be randomized in a ratio 23 mg donepezil SR to 10 mg donepezil IR. Patients who complete the study may be eligible to undergo evaluation for enrollment into the open-label extension study, EG