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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Do not pass it on to others.
Nonsteroidal anti-inflammatory drugs NSAIDs have been widely used for the treatment of arthritic conditions. Drugs in this heterogeneous class alleviate pain and inflammation by inhibiting cyclooxygenase-2 COX Cyclooxygenase-1 COX-1 inhibition has traditionally been associated with increased gastrointestinal GI harm, whereas increased COX-2 selectivity has more recently become associated with greater risk of cardiovascular CV harm. Both celecoxib and etoricoxib are associated with less GI harm than diclofenac despite the similarity of its COX-2 selectivity to celecoxib. Each of the three medicines under consideration is associated with a similar https://plushcare.com overall risk of CV events fatal and nonfatal heart attacks and strokes.
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