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In children and adolescents, there is not sufficient evidence of safety and efficacy of clomipramine in the treatment of depressive states, phobias and cataplexy associated with narcolepsy. The use of clomipramine in children and adolescents years of age in these indications is therefore not recommended see section 4. After a response has been obtained, maintenance therapy should be continued at the optimum dose to avoid relapse. Patients with a history of recurrence require maintenance treatment for a longer duration. As a precaution against possible QTc prolongation and serotonergic toxicity, adherence to the recommended doses of clomipramine is advised and any increase in dose should be made with caution if drugs that prolong QT interval or other serotonergic agents are co-administered see sections 4. Abrupt discontinuation of clomipramine therapy should be avoided because of possible withdrawal symptoms. Therefore, dosage should be stopped gradually after regular use for long duration and the patient should be monitored carefully when clomipramine therapy is discontinued. Higher doses may be needed in some patients, particularly those suffering from obsessional or phobic disorders.

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The usual initial dose of Anafranil is 25mg times per day. Html Your doctor will probably tell to first try to take Anafranil as needed. Com 8.

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We determined whether clomipramine taken as needed increases ejaculation latency in men with premature ejaculation and controls. The study included 8 patients with primary premature ejaculation, 6 with premature ejaculation and erectile dysfunction, and 8 controls. A prospective, double-blind, placebo controlled, crossover design was used that included 2, 3-week periods with clomipramine and placebo.

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