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Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, clomipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as clomipramine, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. See toxicity section below for a complete listing of side effects.

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We determined whether clomipramine taken as needed increases ejaculation latency in men with premature ejaculation and controls. The study included 8 patients with primary premature ejaculation, 6 with premature ejaculation and erectile dysfunction, and 8 controls. A prospective, double-blind, placebo controlled, crossover design was used that included 2, 3-week periods with clomipramine and placebo. During treatment phases subjects took either 25 mg. Daily logs of sexual activities were maintained during treatment phases.

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Leonhard (taken for 3 to 4 years) 15.01.2016

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Anafranil 25 mg Tablet is a brand of the generic Clomipramine Hydrochloride. Anafranil Tablet Clomipramine Hydrochloride. Innovator's Monograph.

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Oliver (taken for 1 to 7 years) 22.08.2018

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To purchase this item you must have a prescription from a doctor. For NHS prescriptions. There is no additional delivery charge.

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