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Potassium-sparing diuretic; used for edema, ascites, HTN, hypokalemia, acne vulgaris, polycystic ovary syndrome, female hirsutism, and to diagnose primary hyperaldosteronism; also improves survival and NYHA functional class, and reduces hospitalizations in NYHA Class IV heart failure. Continue treatment for at least 2 weeks since the maximum response may not be observed until this time. Subsequently, adjust dosage according to patient response. The American Academy of Pediatrics AAP recommends that diuretics be used as add-on therapy in patients unresponsive to other antihypertensive drugs. Allow 72 hours between dosage adjustments due to the gradual onset of action.
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